View abstract. Singh A, Handa SS. Your body requires a healthy balance of antioxidants and free radicals to maintain optimal health (28). Celery seed extracts exhibit CYP-450 (particularly CYP2D6) enzyme inhibitory activity. However, more research is required to verify this effect of celery in humans. Christensen, L. P. and Brandt, K. Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. Celery seed extract may also have antioxidant properties. Ballmer-Weber, B. K., Hoffmann, A., Wuthrich, B., Luttkopf, D., Pompei, C., Wangorsch, A., Kastner, M., and Vieths, S. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Thrombolytic agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of thrombolytic agents. Int J Prev Med 2019;10:55. doi: 10.4103/ijpvm.IJPVM_209_17. Hirschfeld G, Weber L, Renkl A, Scharffetter-Kochanek K, Weiss JM. 3-31-1984;13(14):871-874. Ayurvedic medicine uses celery seed to treat water retention, colds and flu, poor digestion, different types of arthritis and certain diseases of the liver and spleen, according to Penn State Hershey Medical Center. This could change the effects and side effects of these medications. In the UK Women's Cohort Study conducted in 13,958 women (with approximately 4 years of follow-up), consumption of an additional portion of celery (among other plants) was inversely associated with sleep duration.Noorwali 2018, Limited studies in rodents suggest celery seed extract possesses hypoglycemic effects.Yusni 2018, Very limited clinical data exist regarding the effects of celery leaf or seed extract in diabetes. Beier, R. C., Ivie, G. W., Oertli, E. H., and Holt, D. L. HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). Numerous studies show that celery seed extract is an effective treatment of gout and other inflammatory-related diseases. Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Hypoglycemia-associated agents: Herbs (hypoglycemic properties) may enhance the hypoglycemic effect of hypoglycemia-associated agents. This article covers whether weight loss can help with symptoms of gout and offers advice for managing gout through your diet, exercise routine, and, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. DOI: sciencedirect.com/topics/agricultural-and-biological-sciences/apium-graveolens, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. For example, one test-tube study found that celery seed extract fought off H. pylori bacteria, which are found in the digestive tract of certain individuals and may lead to stomach ulcers (25, 26). Celery is a biennial plant that was first cultivated in Europe but is grown and consumed worldwide. Promotes joint and muscle comfort*. View abstract. 3 Cancer Preventive Activity In one in vitro study, it was revealed that luteolin is one of the flavonoids that can inhibit xanthine oxidase. These seeds have usually been treated with chemicals. In an Australian study, mice suffering from arthritis and gout took a combination of Indian celery seed extract and New Zealand green-lipped mussels. Celery seeds can also protect against Irritable Bowel Syndrome, urinary tract infection and gout (x). 1998;60:117-124. Heck AM, DeWitt BA, Lukes AL. Food Chem.Toxicol. A study by the Journal of Pharmaceutical Biology in 2010 showed how the alkaloids, tannins and flavonoids in celery improve mucus production, which in turn controls gastric acid. Therapeutic Research Faculty 2020. Food Chem.Toxicol. If you use celery seed extract, make sure to use sunscreen or sunblock lotions to protect your skin from sunburn. 4) zinc. Ann.Allergy 1985;54(2):166. Taking celery juice with aminopyrine might increase the effects and side effects of aminopyrine. Allergy. Discover essential oils that can aid in reducing gout symptoms. This information is not specific medical advice and does not replace information you receive from your health care provider. Higher doses were associated with elevated liver enzymes.Cui 2013, Avoid use. Avoid use. The most common location of gout pain is the large toe, although it can occur in other joints too. Bull.Acad.Natl.Med 1995;179(1):161-184. However, these benefits have not yet been tested in humans. The coumarin glucoside apiumoside has also been identified. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Ann Dermatol Venereol 1993;120:599-603. Occasional consumption as part of a well-balanced diet is not an issue. Avicenna J Phytomed 2021;11(1):44-53. Gorgus, E., Lohr, C., Raquet, N., Guth, S., and Schrenk, D. Limettin and furocoumarins in beverages containing citrus juices or extracts. J Agric Food Chem. Is apple cider vinegar an effective treatment for gout? Our Celery Seed Extract is concentrated and standardized to contain 85% 3-n-butylphthalide as total phthalides. There is a cross reactivity with all forms of celery, including celery salt, celery root, celery seed and commercial products that contain celery seed, such as Old Bay seasoning. Bleeding may occur. Some people who are allergic to birch pollen may also be allergic to celery seed. The Department of Pharmacology at the University of Singapore put mice on a high-fat diet for eight weeks. Am Fam.Physician 1989;39(4):143-146. Vu N, Nguyen TTT, Parmenter BH, Thouas GA. Safety, efficacy and tolerability of a combination micronutrient and polyherbal preparation (GoutFighter TM) for gout: a single-arm open-label pilot study. Equally important, celery seeds offer high nutritional value. Hypolipidemic and antioxidant activity of mountian celery seed essential oils. 1991;127(6):912-913. Anti-gouty arthritis and anti-hyperuricemia properties of celery seed extracts in rodent models. Celery seed extract is most often used for Cardiovascular Health and Kidney & Urinary Health. 3) pygeum. View abstract. Maso, M. J., Ruszkowski, A. M., Bauerle, J., DeLeo, V. A., and Gasparro, F. P. Celery phytophotodermatitis in a chef. But again, researchers do not know whether those effects apply to humans. Celery has become increasingly popular with dieters because of its high fiber content and the mistaken belief that chewing and digesting the stalks uses more calories than celery contains. Conflicting conclusions have been drawn regarding the rate of absorption of apigenin. This helps your blood vessels to expand and facilitates the smooth circulation of blood and, thus, reduces blood pressure. Taking celery juice with acetaminophen might increase the effects and side effects of acetaminophen. Last medically reviewed on July 23, 2019. A celery seedflavored soda, Dr. Brown's Cel-Ray, is available. 2018;127:237-244. Online ahead of print. Hoerler, S. and Ukiwe, J. Laryngeal edema from celery allergic reaction. (Paris) 1995;27(6):209. Bonnin, J. P., Grezard, P., Colin, L., and Perrot, H. [A very significant case of allergy to celery cross-reacting with ragweed]. Egan, C. L. and Sterling, G. Phytophotodermatitis: a visit to Margaritaville. They have been used as a common treatment for arthritis, gout, menstrual cramps, inflammation and high blood pressure. Among other things, the minerals in celery seeds support bone health and blood sugar regulation. Additionally, celery seed supplements may interact with certain medications. But only about 25% of people who take herbal supplements tell their health care providers. In short, celery is a plant based alternative to preserving and curing organic meat and other products. 5 Healthy Benefits of Adding Celery to Your Diet. The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism. Allergy 1997;52(4):428-431. Tuetun B, et al., Mosquito repellency of the seeds of celery (Apium graveolens L.). Gral N, Beani JC, Bonnot D, et al. Some of the phenolic compounds in celery seeds can cause your skin to become very sensitive to the sun's UV rays, according to Penn State Hershey. Healthline Media does not provide medical advice, diagnosis, or treatment. Silverstein, S. R., Frommer, D. A., Dobozin, B., and Rosen, P. Celery-dependent exercise-induced anaphylaxis. Ding Y, et al. Infrared spectography has detected another compound with a furocoumarin glucoside, isoquercitrin. Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity. Al-Asmari AK, et al. View abstract. More n Vito research is needed to verify these preliminary findings. Healthline only shows you brands and products that we stand behind. In about 450 BC, the Greeks used celery to make a type of wine called selinites, which was given as an award at early athletic games, much like laurel leaves or olive branches. The essential oil produces sedative effects. We include products we think are useful for our readers. Celery and Celery Seed Extract Are Powerful, Proven Healers Ciganda C, et al. Further studies are needed to confirm these results so, to play it safe, monitor your blood pressure if you are taking a celery supplement. 5 Healthy Benefits of Adding Celery to Your Diet, What Is Celeriac? Celery (Apium graveolens) is a plant that grows throughout the world. Here are 10 of the world's healthiest herbs and spices, supported by science. As a member of the parsley family, it is prominent in American cooking. Celery seed oil is a supplement containing a high amount of volatile compounds known as phthalides. Read more: 10 Facts You Need to Know About Food Allergies. All rights reserved. Celery is a popular vegetable, but theres more to this plant than the stalk alone. View abstract. The oil of celery seed is sometimes adulterated with celery chaff oil or d-limonene from less expensive sources. However, there are some safety precautions for the more concentrated forms of celery seed (31). Rueff, F., Eberlein-Konig, B., and Przybilla, B. View abstract. Al-Howiriny T, Alsheikh A, Alqasoumi S, Al-Yahya M, ElTahir K, Rafatullah S. Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats. Our team thoroughly researches and evaluates the recommendations we make on our site. A case of Apium graveolens (Celery) induced hyperthyroidism. Heres what the research says. Carotenoids and colon cancer. DOI: Pauff JM, et al. Maintaining healthy blood sugar levels is important for reducing your risk of type 2 diabetes and heart disease (19, 20). Heres the science behind the popular trend. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. There are a handful of other compounds in celery seed that may exhibit other antioxidant and anti-inflammatory properties. 3-n-butylphthalide (3nB) is another compound from celery that may have benefits against gout inflammation. One common dietary intervention for gout is celery. Since then, the plant has been widely used as a food and for medicinal purposes. Celery continues to be used as a food flavoring and in soaps and gum. Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Allergy, including dermatitis and anaphylaxis (rare), and phototoxicity to celery and its falcarinol content have been described.Christensen 2006, Duke 2002, Khan 2009, Pauli 1985, Raised liver enzymes have been noted in phase 3 trials of dl-3-n-butylphthalide 800 mg/day.Cui 2013, Celery seed has GRAS status when used as a food.Khan 2009 Neurotoxicity in rats due to the seed's chemical constituent falcarinol has been demonstrated.Christensen 2006 While celery root contains furocoumarins (particularly psoralens), the concentration in normal dietary intake is at least 1,000-fold lower than the no observed effect level for developing liver or cancer in rats.Dolan 2010 Limited toxicological studies suggest celery seed extract lacks toxicity at normal dosages.Powanda 2015. Findings from a study performed at Irans Mashhad University of Medical Sciences showed a decrease in high blood pressure in laboratory mice that were fed celery seed extract. Scientific Name(s): Apium graveolens L. var dulce (Mill.) Helps maintain already-normal blood pressure*. Rich in Important Nutrients. In fact, each pill has a higher dosage of celery seed extract plus the addition of the tart cherry, and at a lower price. During June and July, small white flowers bloom and later bear the smooth gray seeds. Tuetun, B., Choochote, W., Kanjanapothi, D., Rattanachanpichai, E., Chaithong, U., Chaiwong, P., Jitpakdi, A., Tippawangkosol, P., Riyong, D., and Pitasawat, B. Repellent properties of celery, Apium graveolens L., compared with commercial repellents, against mosquitoes under laboratory and field conditions. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. Thus, it supports bone structure and strength (3, 4, 10). Can drinking this bright green juice really give your body a healthy boost? Zheng GQ, Kenney PM, Zhang J, Lam LK. Oatmeal isnt the best food if you have gout, but it certainly isnt the worst. Can I Treat the Symptoms of Gout with Turmeric? Cheung MC, Lin LY, Yu TH, Peng RY. Furthermore, consuming celery seed extract with a balanced diet plan could help to manage overall cholesterol levels. Inhibition of hepatic xanthine dehydrogenase and xanthine oxidase was suggested.Dolati 2018, Clinical trials guiding celery dosage are limited. Another study observed similar antibacterial benefits of celery seed extract against certain bacteria, yeast, and mold strains. Fitoterapia. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. For these reasons, you should take herbs under the supervision of a health care provider. (2017). 2000;71:575-582. If you experience any of the following symptoms, get immediate medical attention: Before taking a supplement containing celery seed extract, ask your doctor if you are on any medication that may interact with the herb. WebCelery is rich in a phytochemical known as phthalides. (2019). Bleeding may occur. Lastly, celery seeds also contain magnesium and phosphorus. The seed is used as a spice. View abstract. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information may not fit your specific health circumstances. About one-half of adults in the United States say they have used one or more supplements in the past 30 days. Ground celery seed is often referred to as celery powder. Healthline only shows you brands and products that we stand behind. The effects of celery leaf (apium graveolens L.) treatment on blood glucose and insulin levels in elderly pre-diabetics.